Srisailam can be reached by road from Hyderabad. There is a regular bus service from Hyderabad to Srisailam every half an hour or so and also from Guntur. Srisailam is very well connected by state-run bus service APSRTC (Andhra Pradesh State Road Transport Corporation), KSRTC (Karnataka State Road Transport Corporation), the APTDC (Andhra Pradesh Toursim Development Corporation; visit www.aptdc.in) private luxury bus services, and private taxis from major cities/towns including Hyderabad, Guntur, Tenali, Narsaraopet, Gulbarga, Davangare, Shivamogga, Addanki, Hospet, Machilipatnam, Vijayawada, Avanigadda, Cuddapah, Mahabubnagar, Nalgonda, Devarakonda, Vinukonda, Kurnool, Ongole, Nellore, Mahanandi, Mantralayam, Anantapur, Tirupati, Chirala, Chitradurga, Bangalore, Markapur, Vishakapatnam, Podili, and Hubli. The nearest major towns are Narsaraopet and Kurnool.
The nearest railway stations are Markapur (62 km), Vinukonda (120 km) and Kurnool (190 km) on the Guntur–Hubli section. The nearest major railway stations are Narsaraopet, Kurnool and Nandyal. The nearest rail head is Hyderabad, about 230 km away.
Rajiv Gandhi International Airport serving Hyderabad and located 195 km away from Srisailam is the nearest international airport.